Domeboro is a versatile, medicated soak that soothes skin problems where they start. Get relief at last from your most challenging skin conditions. Use as a medicated soak, compress, or wet dressing. USE DOMEBORO ON SKIN IRRITATION CAUSED BY: Plant Rashes: A red streaky rash with blisters that typically follows an encounter with Poison Ivy, oak, or sumac. Jewelry: Contact dermatitis from jewelry that usually contains nickel. Soaps & Detergents: Contact dermatitis and allergic reactions caused by detergents, soaps, and fragrances in cleaning products. Athlete’s foot: great for soothing itch and burn